Bioactive Small Molecules
Cayman Chemical LOXO-101, Purity: ≥98%, CAS: 1223403-58-4, 10 mg
A pan-Trk inhibitor (IC50s = 2-20 nM for TrkA, TrkB, and TrkC); selective for TrkA, -B, and -C over a panel of 226 kinases at 1 μM; inhibits the growth of CUTO-3.29, KM12, and MO-91 patient-derived cancer cell lines (IC50s = <100, <10, and <10 nM, respectively); reduces tumor growth in a KM12 mouse xenograft model at 60 and 200 mg/kg
Medchemexpress LLC 2,5-Dihydroxyacetophenone | 490-78-8 | MFCD00002343 | 152.15 | 5 G
2,5-Dihydroxyacetophenone, isolated from Rehmannia glutinosa, inhibits the production of inflammatory mediators in activated macrophages by blocking the ERK1/2 and NF-κB signaling pathways. It significantly inhibits NO production by suppressing iNOS expression and decreases levels of pro-inflammatory cytokines TNF-α and IL-6 via down-regulation of their mRNA expression in LPS-stimulated RAW264.7 cells. It also potently inhibits the phosphorylation of extracellular signal-related kinase (ERK) 1/2 and the nuclear translocation of nuclear factor-κB (NF-κB) p65 in LPS-stimulated cells.
- Isolated from Rehmannia glutinosa
- Inhibits production of inflammatory mediators
- Blocks ERK1/2 and NF-κB signaling pathways
- Suppresses iNOS expression
- Decreases pro-inflammatory cytokines TNF-α and IL-6
- Inhibits phosphorylation of ERK1/2
- Inhibits nuclear translocation of NF-κB p65
Medchemexpress LLC 4'-Fluorouridine triphosphate sodium | 97.0% | 568.08 | 100 UL
4'-Fluorouridine triphosphate sodium is a bioactive 5'-triphosphate form of 4'-Fluorouridine (EIDD-2749). It effectively binds to RSV RdRP and is intended for research use only.
- Bioactive 5'-triphosphate form of 4'-Fluorouridine
- Effectively binds to RSV RdRP
- For research use only
Medchemexpress LLC 8-Aminoguanine | 28128-41-8 | 97.19% | 166.14 | 100 MG
8-Aminoguanine is an endogenous purine that inhibits purine nucleoside phosphorylase (PNPase) and induces diuresis, natriuresis, and glucosuria. This product is intended for research use only.
- Inhibits purine nucleoside phosphorylase (PNPase)
- Induces diuresis, natriuresis, and glucosuria
- Exhibits cellular effects on MOLT-4 cell line
Medchemexpress LLC Cbl-b-IN-1 | 2368841-84-1 | 99.66% | 498.62 | 50 MG
Cbl-b-IN-1 (Example 519) is an inhibitor of Cbl-b, with an IC50 of less than 100 nM. It is used in research on immunomodulation. It promotes the secretion of cytokines such as IL-2, IFN-γ, and TNF-α, facilitates T cell activation, and enhances the TCR signaling pathway.
- Inhibitor of Cbl-b with an IC50 of less than 100 nM
- Promotes secretion of cytokines (IL-2, IFN-γ, TNF-α)
- Facilitates T cell activation
- Enhances the TCR signaling pathway
- Suitable for immunomodulation research
Medchemexpress LLC HY-126236 5mg Medchemexpress, 3,5-Diiodothyropropionic acid CAS:1158-10-7 Purity:>98%
Medchemexpress, HY-126236 5mg 3,5-Diiodothyropropionic acid CAS:1158-10-7 3,5-Diiodothyropropionic acid is a thyroid hormone analog, induces α-myosin heavy chain mRNA expression, binds to thyroid hormone receptor (TR) , with K a of 2.40 and 4.06 M -1 for TRα1 and TRβ1, respectively [1] . Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.
Medchemexpress LLC HY-112780 100mg , UC2288 CAS:1394011-91-6 Purity:>98%
HY-112780 100mg UC2288 CAS: 1394011-91-6 UC2288 is a novel, cell-permeable, and orally active p21 attenuator (relatively selective activity for p21), which is synthesized based Sorafenib (HY-10201). UC2288 decreases p21 mRNA expression independently of p53, and attenuates p21 protein levels with minimal effect on p21 protein stability. UC2288 has no inhibition of VEGFR2 and Raf kinases even at 10 μM. Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.
Medchemexpress LLC Methyl 2-(7-hydroxy-2-oxo-2H-chromen-4-yl)acetate | 15991-13-6 | 97.4% | 234.20 g·mol⁻¹ | C12H10O5 | 1 ML
Methyl 2-(7-hydroxy-2-oxo-2H-chromen-4-yl)acetate is a coumarin-derived small-molecule fluorescent compound supplied as a solid or as a ready-to-use 10 mM solution in DMSO. It has a molecular weight of 234.20 g·mol⁻¹ and CAS number 15991-13-6. It is commonly used in fluorescence-based assays and synthetic chemistry where a coumarin fluorophore is required.
- Coumarin-derived fluorescent core for strong fluorescence.
- Available as solid or 10 mM solution in DMSO for convenient use.
- High purity (~97%) suitable for analytical and preparative work.
- Low molecular weight for efficient incorporation into small-molecule probes.
- White to light yellow solid appearance for easy visual inspection.
Apexbio Technology LLC Biapenem 120410-24-4 100mg
Biapenem (120410-24-4) is a small-molecule inhibitor targeting penicillin-binding proteins (PBPs) It is designed to inhibit bacterial cell wall synthesis thereby disrupting cell wall integrity and leading to bacterial cell death Biapenem exerts its biological activity primarily through binding to and inhibiting PBPs In in vitro studies biapenem demonstrates inhibitory activity with IC50 values ranging from 0 1 to 10 g/mL depending on organism susceptibility and assay conditions Based on these pharmacological properties biapenem holds research potential in susceptibility testing antimicrobial combination studies and exploration of bacterial resistance mechanisms
Cayman Chemical NG 25 (hydrochloride hydrate), Purity: ≥98%, 10 mg
An inhibitor of MAP4K2 and TAK1 (IC50s = 21.7 and 149 nM, respectively); also inhibits the Src family kinases Src and LYN (IC50s = 113 and 12.9 nM, respectively) and Abl family kinases (IC50s = 75.2 nM), as well as CSK, FER, and p38α (IC50s = 56.4, 82.3, and 102 nM, respectively); prevents TNF-α-induced IKKα/β phosphorylation and IκB-α degradation in L929 cells at 100 nM; inhibits secretion of IFN-α and IFN-β induced by CpG type B and CL097, respectively, in Gen2.2 cells; decreases cell viability of HCT116KRASWT, and to a greater degree of HCT116KRASG13D, colorectal cancer cells; reduces tumor growth and increases the number of TUNEL-positive tumor cells in a CT26KRASG12D mouse orthotopic model of colorectal cancer
Cayman Chemical Fluzoparib, Purity: ≥98%, CAS: 1358715-18-0, 50 mg
A PARP1 inhibitor (IC50 = 1.46 nM); induces DNA double-strand breaks in wild-type, but not BRCA2-/-, V-C8 cells, as well as BRCA1-/- MDA-MB-436 cells at 1 and 10 µM; inhibits the proliferation of BRCA2-/- V-C8 cells (IC50 = 0.053 µM), BRCA1-/- MDA-MB-436, UWB1.289, and MX-1 cells (IC50s = 0.51, 1.57, and 1.57 µM, respectively), and OVCAR-8 cells containing hypermethylated BRCA1 (IC50 = 1.43 µM); reduces tumor formation in an MDA-MB-436 mouse xenograft model at 1 and 3 mg/kg
Medchemexpress LLC Cl-NQTrp | 185351-23-9 | MFCD34471035 | 100.0% | 394.8 g·mol⁻¹ | C21H15ClN2O4 | 5 MG
Cl-NQTrp is a small-molecule research reagent reported to disrupt preformed fibrillar aggregates of the Tau-derived PHF6 (VQIVYK) peptide and full-length tau protein. Supplied as a high-purity solid, it is intended for in vitro biochemical and cellular studies of tau aggregation and disaggregation.
- Disrupts preformed tau and PHF6 fibrillar aggregates.
- Suitable for in vitro biochemical and cellular assays.
- High purity (99.97%) for reproducible results.
- Soluble in DMSO for stock solution preparation.
- Available in small research pack sizes for screening studies.
Medchemexpress LLC NT-4 Mouse 10ug
NT-4 Protein Mouse is a member of neurotrophins family binding with two distinct receptors TrkB high affinity receptor and p75 low-affinity neurotrophin receptor (p75NTR)
Apexbio Technology LLC hyPerFUsion™ high-fidelity DNA polymerase, 100U
hyPerFUsion™ high-fidelity DNA polymerases are composed of a DNA-binding domain fused to a Pyrococcus-like proofreading polymerase. Because of this, hyPerFUsion™ DNA polymerases produce PCR products with very high speed and accuracy. Also, hyPerFUsion™ DNA polymerases are tolerant of various inhibitors, allowing for robust amplification with minimal optimization. hyPerFUsion™ DNA Polymerase is an ideal choice for cloning and can be used for long or difficult (GC-rich) amplicons. hyPerFUsion™ high-fidelity DNA polymerases have become the choice for even demanding applications like massively parallel high-throughput sequencing of whole genomes.High-Fidelity DNA Polymerases are important for applications in which the DNA sequence needs to be correct after amplification. Its unique structure, a novel Pyrococcus-like enzyme fused with a processivity-enhancing domain, increases fidelity and speed. Other sizes are available. Please inqury us for quote.
Medchemexpress LLC Kaempferide | 491-54-3 | C16H12O6 | 1 ML
Kaempferide is an orally active flavonol isolated from Hippophae rhamnoides L.. It exhibits a broad spectrum of biological activities, including anticancer, anti-inflammatory, antioxidant, antidiabetic, antiobesity, antihypertensive, and neuroprotective effects. The compound induces apoptosis and promotes osteogenesis, making it valuable for osteoporosis research.
- Orally active flavonol
- Exhibiting anticancer, anti-inflammatory, antioxidant, antidiabetic, antiobesity, antihypertensive, and neuroprotective activities
- Induces apoptosis and promotes osteogenesis
- Reduces lipid accumulation and oxidative stress
- Inhibits melanogenesis
- Ameliorates oxidative stress and inflammation in obese models
- Alleviates myocardial ischemia/reperfusion injury