Bioactive Small Molecules
Cayman Chemical ANTIBODY AZD 5363 25mg
A pan-Akt inhibitor (Akt1, 2, and 3 IC50s = 3, 7, and 7 nM, respectively) that also inhibits P70S6K and PKA (IC50s = 6 and 7 nM, respectively) and shows >75% inhibition at 1 μM against ROCK2, MKK1, MSK1, MSK2, PKCγ, PKGα, PKGβ, PRKX, RSK2, and RSK3; inhibits the proliferation of various tumor cell lines both in vitro and in vivo, demonstrating the greatest sensitivity towards breast cancer derived-cells or those with PIK3CA and/or PTEN mutations
Cayman Chemical ANTIBODY trasemIde 10mg
An analytical reference standard categorized as a diuretic; has been abused as a performance-enhancing drug and masking agent in doping in sports; intended for research and forensic applications
QA Bio Inc Ludger A2 Glycan - 20µg
A2 Glycan Synonyms: A2 N-linked oligosaccharide. G2S2, A2G2S2, A2G(4)2S(6)2. • Description: Di-sialylated, bi-antennary complex-type N-glycan (oligosaccharide). • Molecular Weight: 2224 • Purity: >90% pure as assessed by a combination of 1 H-NMR and HPLC. • Sources: A2 glycan is found on many mammalian glycoproteins including serum transferrin, and fibrin. This product is typically purified from the oligosaccharide pool released from fibrin by hydrazinolysis using a combination of HPLC and glycosidase digestion. • Form: Dry. Dried by centrifugal evaporation from an aqueous solution. Contains ammonium salt to stabilise against desialylation.
Cayman Chemical Ennatn B1 5mg
A cyclohexadepsipeptide that has been shown to induce apoptosis in several cancer lines (EC50s ≤ 10 µM) and to decrease the activation of the cell proliferation kinase, ERK (p44/p42); inhibits the multi-drug resistance transporter Pdr5p from S. cerevisiae
Cayman Chemical 2ArachIdonyl GlycRol ethR 5mg
A potent and selective agonist of CB1 and GPR55 (EC50s = 10, 37, and >30,000 nM for CB1, GPR55, and CB2, respectively); binds to cannabinoid (CB) receptor 1 (Kis = 21.2 and >3,000 nM for CB1 and CB2, respectively, in a radioligand binding assay); displays the typical tetrad of CB activities in mice; more chemically stable than 2-AG with an endogenous half-life of hours rather than minutes; 10-fold less potent than 2-AG in eliciting typical CB1-mediated responses; reduces intraocular pressure in rabbits when administered at doses exceeding 50 UG per eye; increases dietary intake and enhances fat consumption in rats given access to both high-carbohydrate and high-fat diets
TARGETMOL CHEMICALS INC TOLCAPONE 100MG
Also available in 5 mg 10 mg 25 mg 50 mg 200 mg 500 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. Tolcapone (Ro 40-7592) is a catechol-O-methyltransferase inhibitor used in the therapy of Parkinson disease as adjunctive therapy in combination with levodopa and carbidopa. purity: 99%
Cayman Chemical ANTIBODY PHT-427 5mg
An inhibitor of Akt and PDPK1 (Ki = 2.7 and 5.2 μM, respectively); binds to the pleckstrin homology binding domain; inhibits PDPK1 and Akt autophosphorylation in BxPC-3 prostate cancer cells (10 µM); reduces tumor growth in BxPC-3, Panc-1, MiaPaCa-2, PC3, SKOV3, A549, and MCF-7 xenograft mouse models (125-250 mg/kg); enhances the antitumor effect of paclitaxel in an MCF-7 breast cancer xenograft mouse model
Medchemexpress LLC CXCR7 antagonist-1 | 1613021-99-0 | 99.9% | 390.41 | 1 ML
CXCR7 antagonist-1 is a CXCR7 antagonist that inhibits the binding of the SDF-1 chemokine (CXCL12) or I-TAC (CXCL11) to the chemokine receptor CXCR7. This compound is useful in preventing tumor cell proliferation, tumor formation, and inflammatory diseases. It is intended for research use only.
- Inhibits binding of SDF-1 chemokine (CXCL12) or I-TAC (CXCL11) to CXCR7
- Prevents tumor cell proliferation
- Prevents tumor formation
- Prevents inflammatory diseases
- Research use only
- Purity: 99.85%
- Molecular weight: 390.41
Cayman Chemical ANTIBODY BAR502 1mg
A dual agonist of GP-BAR1 and FXR (EC50s = 0.2 and 1 μM, respectively); increases the expression of FXR-regulated BSEP, OSTα, and SHP in primary hepatocytes isolated from FXR wild-type mice; increases cAMP-luciferase reporter gene expression in HEK293T cells
Selleck Chemical LLC Nicotinamide Riboside Chloride S2935-25mg
Nicotinamide Riboside Chloride is the chloride salt form of nicotinamide riboside(NR) NR is a new form pyridine-nucleoside of vitamin B3 that functions as a precursor to nicotinamide adenine dinucleotide(NAD) or NAD Nicotinamide riboside chloride is a crystal form of Nicotinamide riboside (NR) chloride Nicotinamide riboside chloride increases NAD[ ] levels and activates SIRT1 and SIRT3 culminating in enhanced oxidative metabolism and protection against high fat diet-induced metabolic abnormalities Nicotinamide riboside chloride is used in dietary supplements
Cayman Chemical ANTIBODY ML-221 10mg
An APJ receptor antagonist (IC50 = 4.8 μM); selective for APJ over AT1 (IC50 = >78 μM); antagonizes apelin 13-induced activation of APJ in cAMP and β-arrestin recruitment assays (IC50s = 0.7 and 1.75 μM, respectively); inhibits proliferation and angiogenesis in Mz-ChA-1 cholangiocarcinoma cells from 5-15 μM; reduces tumor growth in a Mz-ChA-1 mouse xenograft model at 150 μg/kg; reduces sciatic CCI-induced mechanical allodynia and heat hyperalgesia in rats at 10 μg/animal; inhibits pathological angiogenesis and enhances normal vessel recovery in retinal ischemic regions in a mouse model of oxygen-induced retinopathy
Cayman Chemical ANTIBODY RN-1747 5mg
A TRPV4 agonist; selectively induces calcium influx in HEK293 cells expressing human, rat, or mouse TRPV4 (EC50s = 0.77, 4.1, and 4 µM, respectively) over HEK293 cells expressing human TRPV1, TRPV3, or TRPM8 (EC50s = >100, >30, and >30 µM, respectively); induces inward current in Xenopus oocytes expressing human TRPV4 at 10 µM; topical administration of RN-1747 induces hypothermia in rats
Cayman Chemical AtractylenolIde II 5mg
A sesquiterpene with diverse biological activities; inhibits proliferation of, as well as halts the cell cycle at the G2/M phase and induces apoptosis in, DU145 and LNCaP prostate cancer cells at 50 and 100 µM; prevents irradiation-induced cutaneous and intestinal ulcers in mice at 60 mg/kg
![eMolecules 2752-65-0 | Gambogic acid | Broadpharm628.762 | C38H44O8 | 97.000 | CC(C)=CCC[C@@]1(C)Oc2c(CC=C(C)C)c3O[C@@]45[C@H]6C[C@@H](C=C4C(=O)c3c(O)c2C=C1)C(=O)[C@]5(C\C=C(\C)C(O)=O)OC6(C)C | 1g | 249969320](https://assets.fishersci.com/TFS-Assets/CCG/product-images/502203375.JPG-250.jpg)
eMolecules 2752-65-0 | Gambogic acid | Broadpharm628.762 | C38H44O8 | 97.000 | CC(C)=CCC[C@@]1(C)Oc2c(CC=C(C)C)c3O[C@@]45[C@H]6C[C@@H](C=C4C(=O)c3c(O)c2C=C1)C(=O)[C@]5(C\C=C(\C)C(O)=O)OC6(C)C | 1g | 249969320
Gambogic acid | Broadpharm | 2752-65-0628.762 | C38H44O8 | 97.000 | CC(C)=CCC[C@@]1(C)Oc2c(CC=C(C)C)c3O[C@@]45[C@H]6C[C@@H](C=C4C(=O)c3c(O)c2C=C1)C(=O)[C@]5(C\C=C(\C)C(O)=O)OC6(C)C | 1g | 249969320
Medchemexpress LLC 4-(3-(5-chloro-2-methoxyphenyl)thioxureido)-1-ethyl-1H-pyrazole-3-carboxamide | 957485-64-2 | 99.3% | 100 MG
FPH2 is a small-molecule research compound that induces functional proliferation of primary human hepatocytes and is used in studies toward therapeutics for liver diseases. In vitro, it increases hepatocyte nuclei count and the number of nuclei undergoing mitosis in a concentration-dependent manner while maintaining liver-specific functions.
- Induces proliferation of primary human hepatocytes.
- Maintains liver-specific functions during proliferation.
- Shows concentration-dependent activity in vitro.
- High purity suitable for research applications.
- Stable as a powder when stored at -20°C for long-term storage.